منابع مشابه
Force-induced DNA slippage.
DNA containing repetitive sequences displays richer dynamics than heterogeneous sequences. In the genome the number of repeat units of repetitive sequences, known as microsatellites, may vary during replication by DNA slippage and their expansion gives rise to serious disorders. We studied the mechanical properties of repetitive DNA using dynamic force spectroscopy and found striking difference...
متن کاملOptimization of the Analysis of Almond DNA Simple Sequence Repeats (SSRs) Through Submarine Electrophoresis Using Different Agaroses and Staining Protocols
Simple sequence repeat (SSR markers or microsatellites), based on the specific PCR amplification of DNA sequences, are becoming the markers of choice for molecular characterization of a wide range of plants because of their high polymorphism, abundance, and codominant inheritance. Different methods have been used for the analysis of the SSR amplified fragments being submarine agarose electropho...
متن کاملDynamics of force-induced DNA slippage.
We study the base pairing dynamics of DNA with repetitive sequences where local strand slippage can create, annihilate, and move bulge loops. Using an explicit theoretical model, we find a rich dynamical behavior as a function of an applied shear force f: reptationlike dynamics at f=f(c) with a rupture time tau scaling as N3 with its length N, drift-diffusion dynamics for f(c)<f<f(*), and a dyn...
متن کاملDynamic aspects of DNA DNA-slippage and nucleosome dynamics
xi 1. Properties of DNA 1 1.1. The structure of DNA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2. Thermodynamics of DNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.2.1. Binding free energies of double stranded DNA . . . . . . . . . . . . 4 1.2.2. Denaturation of long DNA molecules . . . . . . . . . . . . . . . . . 5 1.2.3. DNA melting of homogenous sequences . ....
متن کاملSimple model of collective transport with phase slippage.
We present a mean-field analysis of a many-body dynamical system which models charge-densitywave transport in the presence of random pinning impurities. Phase slip between charge-density-wave domains is modeled by a coupling term that is periodic in the phase diA'erences. When driven by an external field, the system exhibits a first-order depinning transition, hysteresis, and switching between ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1992
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/20.2.211